The suPAR Health test serves as a valuable tool for predicting the likelihood of developing an illness. Taking this test can provide insight into the presence of potentially serious diseases that may manifest within the next 10 years^{1,Eugen-Olsen, J., Andersen, O., Linneberg, A., Ladelund, S., Hansen, T. W., Langkilde, A., Petersen, J., Pielak, T., Møller, L. N., Jeppesen, J., Lyngbaek, S., Fenger, M., Olsen, M. H., Hildebrandt, P. R., Borch-Johnsen, K., Jørgensen, T., & Haugaard, S. B. (2010). Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population. Journal of internal medicine, 268(3), 296–308.2Hayek, S. S., Sever, S., Ko, Y. A., Trachtman, H., Awad, M., Wadhwani, S., Altintas, M. M., Wei, C., Hotton, A. L., French, A. L., Sperling, L. S., Lerakis, S., Quyyumi, A. A., & Reiser, J. (2015). Soluble Urokinase Receptor and Chronic Kidney Disease. The New England journal of medicine, 373(20), 1916–1925.}.

A high suPAR score indicates the existence of an underlying significant factor. However, this circumstance presents an advantageous opportunity to identify the root cause at an earlier stage, ultimately leading to the potential prevention of disease.

Conversely, a low suPAR score in the test implies a positive state of health and suggests that your body can “tolerate your lifestyle” without any immediate concerns.

At our Longevity clinic in Hellerup, we draw your blood with a simple minimal invasive blod test. The procedure only takes a few minutes, and you get your test result within a few days.

The suPAR Health test costs 950 DKK. When you purchase one of our larger health examinations, Health Check, Health Baseline, or Health Intelligence, a suPAR test is included in the price. Since the test is designed to be taken over time repeatedly, we created a 10 x SuPar Health test package at a 30% discount.

We recommend that you take a suPAR Health test once every 3-6 months to keep an eye on your immune system’s activity and to have something to compare your levels to in the long run.

Smokers can lower their suPAR by an average of 1.0 ng/ml by quitting smoking. The result can already be measured after 4 weeks^{3Eugen-Olsen, J., Ladelund, S., & Sørensen, L. T. (2016). Plasma suPAR is lowered by smoking cessation: a randomized controlled study. European journal of clinical investigation, 46(4), 305–311.}.

Less active people can lower their suPAR by 0.4 ng/ml by increasing the frequency of their exercise protocols. Individuals with a BMI of 35+ can lower suPAR by 0.5 ng/ml by losing weight.

Individuals who regularly eat unhealthy food can lower their suPAR by 0.3 ng/ml by switching to a healthy diet^{4Haupt, T. H., Kallemose, T., Ladelund, S., Rasmussen, L. J., Thorball, C. W., Andersen, O., Pisinger, C., & Eugen-Olsen, J. (2014). Risk factors associated with serum levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor in a general population. Biomarker insights, 9, 91–100.}.

People who suffer from bad sleep, can reduce their suPAR levels significantly by adjusting their sleep rhythm and sticking to a consistent sleep cycle.

Stressed people can reduce their suPAR levels by 0.3 ng/ml by taking proactive measures to remove the stressful factors from their everyday lives.

The association between alcohol consumption and suPAR is not completely clear, but alcoholic liver disease causes very high suPAR levels^{5Sjöwall, C., Martinsson, K., Cardell, K., Ekstedt, M., & Kechagias, S. (2015). Soluble urokinase plasminogen activator receptor levels are associated with severity of fibrosis in nonalcoholic fatty liver disease. Translational research: the journal of laboratory and clinical medicine, 165(6), 658–666.}.

If you reduce your suPAR level, you automatically reduce your suPAR biological age as well, as the two are interconnected. To reduce it, the same health interventions apply as for reducing suPAR.

The suPAR Health test reveals your biological age and the rate at which you are aging. Generally speaking, people with high suPAR age at a faster rate than normal (e.g. 1.4 years per year), while those with low suPAR age at a slower rate (e.g. 0.75 years per year). These people have actually managed to slow down their aging process^{6Rasmussen, L. J. H., Caspi, A., Ambler, A., Danese, A., Elliott, M., Eugen-Olsen, J., Hariri, A. R., Harrington, H., Houts, R., Poulton, R., Ramrakha, S., Sugden, K., Williams, B., & Moffitt, T. E. (2021). Association Between Elevated suPAR, a New Biomarker of Inflammation, and Accelerated Aging. The journals of gerontology. Series A, Biological sciences and medical sciences, 76(2), 318–327.}.

Inflammation is your body’s biological response either to the presence of foreign substances (bacteria, viruses, toxins, etc.) or to injury. It is your body’s way of protecting itself by creating an area of increased blood flow to the affected area, allowing the immune system to begin healing quickly.

Acute inflammation is a short-term response to an injury or infection that involves your body’s immune system. This could be a sprained ankle or a common virus infection and usually lasts for a few days with signs and symptoms like localized redness, swelling, warmth, headaches, muscle pain, etc.

Chronic inflammation, on the other hand, is what happens when the acute inflammation can not resolve the situation. The body’s immune system does not turn off after the initial response and instead of healing, the inflammation will stay in your body for weeks, months – or even years. The signs of chronic inflammation are often ‘invisible’, as they are spread throughout the body and harder to localize. As a result, this type of inflammation is harder to resolve and detect, and thus more dangerous as it may lead to cardiovascular disease, autoimmune disorders, cancer and neurological disease.

Chronic inflammation and a high suPAR level are often caused by lifestyle factors such as poor diet, smoking, and lack of exercise^{7Rasmussen, L. J. H., Petersen, J. E. V., & Eugen-Olsen, J. (2021). Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation. Frontiers in immunology, 12, 780641.}, and can be exacerbated by environmental factors such as pollutants^{8Fagerberg, B., Borné, Y., Barregard, L., Sallsten, G., Forsgard, N., Hedblad, B., Persson, M., & Engström, G. (2017). Cadmium exposure is associated with soluble urokinase plasminogen activator receptor, a circulating marker of inflammation and future cardiovascular disease. Environmental research, 152, 185–191.} and allergens. A healthier lifestyle can lead to a lower suPAR level, which requires adjusting known lifestyle factors such as smoking, alcohol, sleep, diet, exercise^{9Haupt, T. H., Rasmussen, L. J. H., Kallemose, T., Ladelund, S., Andersen, O., Pisinger, C., & Eugen-Olsen, J. (2019). Healthy lifestyles reduce suPAR and mortality in a Danish general population study. Immunity & ageing : I & A, 16, 1.}, and stress^{10Bourassa, K. J., Rasmussen, L. J. H., Danese, A., Eugen-Olsen, J., Harrington, H., Houts, R., Poulton, R., Ramrakha, S., Sugden, K., Williams, B., Moffitt, T. E., & Caspi, A. (2021). Linking stressful life events and chronic inflammation using suPAR (soluble urokinase plasminogen activator receptor). Brain, behavior, and immunity, 97, 79–88.}.

suPAR was discovered by Danish researcher and biochemist Jesper Eugen-Olsen, who is part of the Scientific advisory board of Aetas Diagnostics. Back in 1999, he demonstrated a link between the level of suPAR protein in the blood and the activity of HIV patients’ immune systems^{11Sidenius, N., Sier, C. F., Ullum, H., Pedersen, B. K., Lepri, A. C., Blasi, F., & Eugen-Olsen, J. (2000). Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection. Blood, 96(13), 4091–4095.}. Since then, he has founded the company ViroGates, which has developed and patented the suPAR test.